When handling clinical, R&D or any small batch of high value products, the capability to minimise the product waste to virtually zero is key.
Among this kind of productions, we often find non-perfectly flowing powders and irregular powders, which present difficulties in obtaining an acceptable dosing accuracy.
There are also powders which are so hygroscopic, sticky or heat-sensitive that the typical filling processes can alter their properties and features.
Highly higroscopic and sticky powders
Irregular types of powders, cannot be accurately filled with vacuum-pressure dosing disk
Heat-sensitive powders, cannot be filled with augers without risking of altering their features
Citostatic products, posing hazard to operators
High value products in small and clinical batches
Non-flowable powders with tendency to create bridges
Powder that melts at 30° C
Microspheres which can’t be altered in any way during the filling process
Powders crystalised in bulk (instead of lyophilised in vials)
Innovative donut™ powder filling system via vacuum-assisted pick and place
Specifically designed hopper suitable to end-of-batch procedure leaving minimum product residual
Powder dosing starting from 20 mg
Choice among available barrier technologies: oRABS, cRABS and isolator, including integrated VHP decontamination system and transfer systems (RTP, SART system, etc.)
Zero-loss logic process thanks to robots taking care of all the operations (filling, stoppering, capping)
All vials are closed before exiting the machine
100% check weighing system
Possibility to run RTU vials in nests or trays
Peristaltic pumps for MediaFill purposes