Big volume filling of dry syrups

What types of powders can be used for dry syrup filling?

The types of powders suitable for dry syrup filling are diverse and depend on the specific formulation and desired properties of the final product. Common categories include:

•    Active Pharmaceutical Ingredients (APIs): These are the core medicinal substances that provide the therapeutic effect. Examples include antibiotics, antivirals, and analgesics.   

•    Excipients: These are inactive substances that serve various purposes, such as: 

• Sweeteners: Enhance the taste and palatability of the syrup.   
• Flavorings: Improve the overall taste experience.   
• Coloring agents: Provide visual appeal and product identification.   
• Buffers: Maintain the pH stability of the reconstituted syrup.   
• Suspending agents: Help to disperse the powder particles evenly in the liquid.   
• Flow enhancers: Improve the powder's flowability during filling.   
• Preservatives: Extend the shelf life of the reconstituted syrup.

Is Romaco dry syrup filling equipment scalable for different production volumes?

In terms of our macro dosing machines capacity, we invite you to check our portfolio on the website https://www.romaco.com/products/powder-liquid-filling. Our sales team is available for more specific inquiries, do not hesitate to contact us at [email protected] or [email protected]

Can I request customization for specific filling requirements?

Romaco is open to collaborate with Pharmaceutical Companies, CMOs and CDMOs in order to accommodate their requirements for filling machines.

Are there any specific storage requirements for dry syrups?

While specific requirements can vary depending on the individual formulation and packaging, here are the key general considerations for dry syrup storage:
1. Temperature Control:
•    Dry syrups are generally sensitive to high temperatures. Elevated temperatures can accelerate degradation processes, such as chemical decomposition, loss of potency, or physical changes like caking.   
•    Therefore, storage within a controlled temperature range is crucial. Typically, this range is between 15°C and 30°C (59°F and 86°F), often referred to as "room temperature."
•    However, some formulations may require even cooler storage conditions, such as refrigeration (2°C to 8°C or 36°F to 46°F). Always refer to the specific product's stability data and manufacturer's recommendations for precise temperature limits.   
2. Humidity Control:
•    Moisture is a significant concern for dry syrups. Excessive humidity can lead to moisture absorption, which can cause: 
o    Clumping or caking of the powder
o    Reduced flowability
o    Premature activation of the ingredients
o    Degradation of moisture-sensitive components
•    Storage in a dry environment with controlled humidity is essential. Relative humidity levels should ideally be maintained below 65% or as specified by the product's storage instructions.
•    Proper packaging plays a vital role in protecting the dry syrup from moisture ingress.
3. Light Protection:
•    Some active pharmaceutical ingredients (APIs) and excipients in dry syrups are sensitive to light exposure. Light can initiate or accelerate degradation reactions, leading to a loss of potency or the formation of undesirable byproducts.   
•    Storage in opaque containers or in a dark environment is recommended to protect light-sensitive dry syrups.
4. Packaging Integrity:
•    The packaging of the dry syrup must remain intact throughout storage to prevent contamination, moisture ingress, and exposure to light.
•    Containers should be inspected regularly for any signs of damage, such as cracks, leaks, or punctures.
5. Storage Conditions Documentation:
•    Accurate and detailed records of storage conditions, including temperature and humidity, should be maintained. This documentation is essential for quality control and traceability.
Important Note:
•    It is imperative to consult the specific storage instructions provided by the manufacturer of each individual dry syrup product. These instructions are based on extensive stability studies and will provide the most accurate and reliable guidance.
•    Additionally, relevant pharmacopeial guidelines (e.g., USP, EP) and local regulatory requirements should be followed.

What types of closures can be used with Romaco filling equipment?

Romaco filling equipment can accommodate various closing methods, such as screw caps, CRCs, Tamper-Evident Caps, aluminum caps, flip-off caps.

What kind of troubleshooting support do you offer if issues arise?

Romaco offers various solutions for Troubleshooting support:
•    Customer service via hotline where our remote technicians provide live support to customers
•    Ticketing system for remote support
•    Machine user manual which already contains basic troubleshooting and the alarm list
•    Dedicated training sessions with related documentation
•    On-site intervention by our technicians.