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Pharmaceutical granulation line.
Wet granulation process integrated into a single frame.
The granulation line integrates all options for the pharmaceutical wet granulation process into a single frame and control panel:
Mixing and granulation: high shear mixer granulator
Drying, granulation, coating: fluidised bed dryer
Calibration: conical and cylindrical calibrators
High shear mixer granulator
Fluidised bed dryer
Main features
The high shear mixer granulator is designed to optimise the wet granulation process. Used to turn a heterogeneous fine powder mixture in a short time and with repeatability into a uniform granulation with increased particle size and higher density, offering good flow and compaction properties.
In the ITF machine, the drying process is carried out to reduce the humidity in the granule. Hot, dry air is introduced through a vacuum generated inside the unit. The wet solids rise from the bottom and are suspended in a current of air, remaining in a fluidised state. The heat transfer and the low air humidity in direct contact with the wet granulate allow the evaporation of the water or solvents, reducing their moisture.
The process of granulation by top spraying in the ITF machine allows the granulation process to be carried out in a fluid bed. The movement of the powder in a fluidised state is combined with the spraying of a binder solution. This combination makes it possible to increase the particle size generating a granulate.
The coating process in the ITF is carried out by combining the spraying of the coating suspension on the microgranules and a fluid bed movement. Spraying is done from the bottom through tubular (Wurster system)
IGT Complete wet granulation process is ATEX certified.